Alka Goyal

DMCH Lahersarai Darbhanga, India

Title: The study of serum PCSK9 in Chronic Kidney Disease

Abstract

Introduction: Chronic Kidney Disease (CKD) is associated with abnormal kidney function and a progressive decline in GFR ≤ (60ml/min/1.73m2) and irreversible reduction in nephrons. PCSK-9 (Proprotein convertase subtilisin/kexin type 9) is a new biomarker which has been observed to be raised in CKD patients.

Aim: To study relationship of serum PCSK-9 with different parameters like age, gender and Body Mass Index (BMI) in CKD patients.

Materials and Methods: The study was conducted in department of Biochemistry of Dharbanga Medical College, Laheriasarai from 1st May 2018 to 31st December 2018. 60 patients suffering from CKD in between 16 years to 65 years of age of both genders were consecutively enrolled. Serum PCSK9 was estimated using Ultra-Sensitive Human PCSK9 ELISA EK1147 PicoKineTM (BOSTER) and Quetelet Index ( Weight in Kgs/ Height in meters2) was used to calculate BMI. Results were statistically analysed.

Observation: Serum PCSK 9 levels didn’t show any statistically relevant relationship with age. However, levels were significantly more in females (2390.05±1088.78 ng/ml) than in males (1658.10±1245.78 ng/ml). Moreover, its levels also increased as BMI increased. With BMI<25 kg/m2 it was 1312.50 ± 1128.78 ng/ml (Mean ±SD), with BMI 25-29 kg/m2 it increased to 2186.62 ± 1185.62 ng/ml (Mean ±SD) and with BMI >- 30 Kg/m2 it reached 2864.47 ± 753.39 ng/ml(Mean ±SD). This rise was statistically significant (p,-0.05).

Conclusion: This study concluded that serum PCSK9 was significantly higher in females suffering from CKD and with increase in BMI, its levels increase.

Biography

Alka Puria is a distinguished Senior Lecturer at Government Medical College, Patiala, India, where she actively contributes to medical education and research. Her academic prowess is evident through her outstanding achievements, having secured top ranks in both the MBBS and MD university examinations. During her postgraduation she demonstrated exceptional academic excellence, and earned distinctions in her theory examinations and received a prestigious gold medal for her outstanding performance in MD university examination. Beyond her academic accomplishments, she serves as a mentor for postgraduate students, guiding them through their thesis and research endeavors. Her dedication to medical education and commitment to excellence make her a respected figure in this field. She has various research publications to her credit. She has been an active participant in various reputed national & international conferences including oral paper presentations, poster presentations and guest lectures. She also has been awarded for best oral paper and poster in BAPCON 2020, and honored with Shantiniketan award in ANCIAPI 2023 for best oral paper presentation. She is a life time member of IMA, and AMBI of India. Her passion for teaching and research continues to inspire the next generation of healthcare professionals, making a significant impact on the medical community.

2nd World Congress on Heart and Cardiovascular Diseases

Alka Goyal

Title: The study of serum PCSK9 in Chronic Kidney Disease

Abstract

Biography

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