Virtual Conference
Heart Conference

Alina Bektimirova

I.M. Sechenov First Moscow State Medical University, Russian Federation

Title: The effects of interval hypoxic-hyperoxic training on the cardiovascular profile in patients with cardiovascular pathology in the early stages after COVID-19 infection


Objective: To assess the effects of interval hypoxic-hyperoxic training (IHHT) on arterial stiffness in patients with cardiovascular diseases (CVD) in the early stages after coronavirus infection. 

Design and method: The study included 22 people (10 men, 12 women) with CVD who underwent laboratory-confirmed COVID-19 with a severe lung damage according to computer tomography results 1-3 months ago and were admitted to the local hospital. All patients underwent 15 40-minute sessions of IHHT (alternating the supply of a hypoxic gas mixture with 10–12% O2 with the supply of a hyperoxic gas mixture with 30–35% O2) for 3 weeks. Arterial stiffness, systolic (SBP) and diastolic (DBP) blood pressure at rest were selected as the primary endpoints. The indicators were defined by pulse wave velocity, cardio-ankle vascular indexes (RCAVI and LCAVI), augmentation index and ankle brachial index (ABI). The data was collected before and after the 3-week exposure. 

Results: After 15 IHHT sessions, there were detected positive changes in the arterial stiffness parameters as the augmentation index decreased from 20 ± 2 to 14 ± 3. SBP and DBP lowered to normal values from 135.6 +/- 3.7 and 92.0 +/-2.4 before IHHT to 130.5 +/- 2.7 and 88.3+/- 1.9 after IHHT consequently. RCAVI and LCAVI showed the changes of the pre- and post-intervention values (RCAVI from 7.8 +/- 1.2 to 7.4 +/- 1.1 and LCAVI from 7.7 +/- 1.2 to 7.3 +/- 1.1). There was no significant decrease in ABI parameters after the IHHT.

Conclusions: The results suggested that the course of IHHT in patients with CVD in the early stages after the infection with COVID-19 can be used as an effective method to improve the arterial stiffness and correct blood pressure.


Bektimirova Alina is a PhD student at I.M. Sechenov First Moscow State Medical University.