A In order to study the rigidity of the arterial bed in patients with chronic heart failure (CHF) infected with the human immunodeficiency virus (HIV), the total peripheral vascular resistance (TPVR) was calculated. Increased arterial stiffness, determined by calculating the TPVR indicator of more than 210 kPa•s/l, is formed in patients with HIV infection against the background of chronic heart failure under the influence of smoking and the inflammatory process, contributing to an increase in the functional class of CHF and the development of ventricular cardiac arrhythmias. In patients with increased peripheral vascular resistance, the level of NT - proBNP in the blood plasma and the concentration of caspase-6 re higher, anemia and thrombocytopenia are more often detected. Under the influence of increased arterial stiffness, HIV-infected patients experience cardiac remodeling in the form of left ventricular hypertrophy, left atrium dilation, diastolic and systolic heart failure, and pulmonary arterial hypertension.

Plasma NT - proBNP and serum caspase-6 levels increase significantly in patients with increased arterial stiffness. An increase in TPVR to 210.88 kPa•s/l predicts a worsening of CHF with NT - proBNP values reaching 1500 pg/ml and higher. An increase in TPVR to 210 kPa•s/l increases the chances of developing diastolic dysfunction by 2.77 times, and increases the chances of developing severe CHF with NT level - proBNP ≥ 1500 pg/ml by 4.29 times, determining the clinical and prognostic significance of calculating this indicator in patients with CHF infected with HIV.

Olga Goryacheva has completed her PHD at the age of 30 years from Perm State Medical University named ac. E.A. Wagner, Russia. She is the Associate Professor of Outpatient Therapy department of PSMU named ac. E.A. Wagner. She has 44 publications and her publication h-index is 6, RI score 11,7. She is interested in Chronic heart failure, HIV, myocardial infarction. Her PHD work was devoted to the topic of relationships of hemodynamic indexes and antioxidant system in patients with myocardial infarction (2011).  Since 2017 she is interesting of HIV-CHF interactions and nowadays is completing a second scientific work. Combines the work of a medical teacher and cardiologist with ultrasound diagnostics