In recent years, the life expectancy of persons living with HIV infection has increased significantly. It is no secret that many different cardiovascular diseases have been described in patients with HIV infection.

Purpose of the study: To study the features of target organ damage in patients with chronic heart failure infected with the human immunodeficiency virus, depending on the control of blood pressure in a single-stage clinical study.

Design and methods: 240 patients with HIV infection were examined in a multidisciplinary hospital. The diagnosis of chronic heart failure (CHF) was confirmed by the determination of the level of the N-terminal fragment of the brain natriuretic peptide (NT-proBNP) in the blood plasma, echocardiographic criteria, and a combination of clinical signs. Subsequently, patients with CHF and elevated blood pressure up to 140/90 mm Hg and above (40 people) and with blood pressure from 91/61 to 139/89 mm Hg (76 people) were selected. All patients underwent a study in the blood serum of the level of tissue inhibitor of metalloproteinases-1 (TIMP-1), cystatin C to assess the filtration function of the kidneys, as well as non-invasive arteriography with the determination of daytime blood pressure for 3 hours using TensioMed ArterioGraph 24 medical equipment. The obtained data were processed using the Statistica 13.0 program (Russia).

Results: In patients with CHF and HIV infection with BP ≥140/90 mm Hg and above, it. In patients with CHF and HIV infection with BP ≥140/90 mm Hg and above, it was associated with subclinical arterial disease, manifested by an increase in augmentation indices and pulse wave velocity, as well as an increase in the concentration of TIMP-1 in the blood serum. In patients with CHF and HIV infection with BP ≥ 140/90 mm Hg and above, it was accompanied by a decrease in the filtration function of the kidneys, which was confirmed by a higher level of cystatin C in the blood serum and a lower glomerular filtration rate calculated on the basis of cystatin C using the CKD- EPIcys. Heart muscle damage in patients with CHF, HIV, and elevated blood pressure ≥ 140/90 mm Hg is associated with more frequent left ventricular diastolic dysfunction, left ventricular hypertrophy, and left atrial dilatation. In patients with CHF and HIV infection, BP ≥140/90 mm Hg is associated with a higher incidence of heart failure, thrombocytopenia and a history of serum iron deficiency, as well as taking protease inhibitors and nucleoside reverse transcriptase inhibitors.

Olga Goryacheva has completed her PHD at the age of 30 years from Perm State Medical University named ac. E.A. Wagner, Russia. She is the Associate Professor of Outpatient Therapy department of PSMU named ac. E.A. Wagner. She has 44 publications and her publication h-index is 6, RI score 11,7. She is interesting in Chronic heart failure, HIV, myocardial infarction. Her PHD work was devoted to the topic of relationships of hemodynamic indexes and antioxidant system in patients with myocardial infarction (2011).  Since 2017 she is interesting of HIV-CHF interactions and nowadays is completing a second scientific work. Combines the work of a medical teacher and cardiologist with ultrasound diagnostics.