Objective: To investigate the predictive value of the Left Ventricular Global Function Index (LVGFI) for Major Adverse Cardiovascular Events (MACE) in patients with Acute Myocardial Infarction (AMI) undergoing Percutaneous Coronary Intervention (PCI) and to compare its predictive efficacy with Left Ventricular Ejection Fraction (LVEF). 

Methods: Between December 2020 and June 2022, 209 AMI patients who underwent PCI treatment were included in this study. All patients underwent routine cardiac ultrasound within 48 hours after the procedure, and LVGFI values were calculated. Follow-up on the occurrence of MACE one year after PCI surgery. Multiple factor COX survival analysis was used to evaluate the correlation between LVGFI and clinical outcomes. The predictive value of LVGFI and LVEF was analyzed by the receiver working characteristic (ROC) curve.

Result: During the follow-up period, a total of 43 patients (20.6%) experienced MACE. The LVGFI level in the MACE group was significantly lower than that in the non-MACE group (P<0.001). Cox survival analysis showed that LVGFI was still an independent factor for predicting MACE (HR 0.796, 95% CI 0.642–0.989, P<0.001). The ROC curve analysis showed that the AUCs of LVGFI and LVEF in predicting MACE events were 0.822 and 0.745, respectively. The sensitivities were 88.6% and 67.5%, and the specificities were 62.8% and 74.4%. Kaplan-Meier analysis showed that patients with LVGFI< 22.37% had a higher incidence of MACE (Log-rank P<0.001). 

Conclusions: LVGFI is an independent predictor of MACE in patients with AMI and PCI. LVGFI showed better predictive performance compared with LVEF.