The report is devoted to a detailed analysis of the features of the action of various drugs used in the treatment of arterial hypertension and atherogenic dyslipidemia, depending on their ability to dissolve in the fatty media of the body (lipophilicity). The authors draw connections between the severity of the degree of lipophilicity of drugs and the parameters of their pharmacokinetics, nuances of drug interactions, manifestations of clinical effects and organoprotection, as well as their ability to influence the prognosis of comorbid patients. Using the example of ACE inhibitors, calcium channel blockers and statins, the authors explain the applied significance of such pharmacological parameters as binding to plasma proteins and volume of distribution and form the reader's understanding of the importance of routine use of these values in order to obtain clinical benefits for their patients.

Anton Skotnikov, MD, PhD - In 2011, he defended his PhD thesis on the topic: "Features of the course, treatment and prognosis of acute coronary syndrome without ST segment elevation in patients with iron deficiency anemia". Since 2015, he has been working as the associate professor at the Department of Medical and Social Expertise, Emergency and Outpatient Therapy at the Institute of Professional Education of the I.M. Sechenov First Moscow State Medical University. Since 2022, he has been working as the head of the Department of Pharmacology and Clinical Pharmacology of the Russian State Social University. Teaching a fundamental discipline combines with a discussion of the applied aspects of prescribing medicines in real clinical practice, as well as evidence-based medicine. Since 2015, he has been the founder and head of the "Scientific Research Center for Comorbid Pathology "Rational Medicine"