Akildzhonov Firdavsdzhon RustamdzhonovichNational Medical Research Center for Cardiovascular Surgery, Russian Federation
Title: Global deformation of left ventricle: Chemotherapy-induced cardiotoxicity
Abstract: The achievements of targeted therapy of oncological diseases over the past decades have significantly increased the survival rate of patients who verified malignant neoplasm. It is known that some chemotherapeutic agents (for example, anthracyclin, trastuzumab), commonly used in the treatment of malignant neoplasms, have a cardiotoxic effect. One of the most unfavorable side effects is the development of early left ventricular dysfunction (LV) and the progression of heart failure. Global longitudinal deformation of the left ventricle (GLS) reveals early subclinical dysfunction of myocardial LV and can be used in patients receiving chemotherapy. The prognostic value of the GLS assessment to identify cardiotoxicity associated with chemotherapy has little studied. Progress in the treatment of cancer over the past decades has improved the long-term survival of patients but increased the frequency of the development of cardiotoxicity. In this review, we summarize the existing literature on the global deformation of the myocardium of the left ventricle in the longitudinal direction (GLS) and represent the current aspects of the pathogenesis of cardiotoxicity in patients receiving chemotherapy.
Keywords: cardiotoxicity, global longitudinal deformation of the left ventricle, trastuzumab.
To be updated